This course addresses the impact of the human genome project on understanding human genetic disease, focusing on the invaluable role for animal models of diseases in augmenting evaluation of genomic information to develop strategies for precision medicine. Animal models are an invaluable asset in reaching this goal because they allow experimental manipulations that go far beyond what is possible in human patients.

One of the most important characteristics of life is the ability to reproduce. In order to produce new life, multicellular organisms evolved specialized cells whose only purpose is reproduction ¿ the germ cells. Germ cells are the only cells that persist from one generation to the next and are often called immortal. We will decipher how these totipotent stem cells function in order to faithfully create the next generation of organisms.

MLBS sits on the Eastern Continental Divide providing an incredible diversity of freshwater habitats. Proficiency in ichthyology will be developed through field trips and lab work. Themes include: fish ID; patterns and drivers of diversity; interactions on individual, population, community and ecosystem levels; evolution; and influences of human activities. Students will design and conduct a research project and present at a class symposium.

Emphasis on the functions and integration of human nervous, cardiovascular, respiratory, digestive, and renal systems in maintaining homeostasis, and by extension, health. Normal function, from cells to organs, of each system provides a foundation for study of mechanisms that lead to dysfunction and the identification of potential therapeutic targets and strategies.

In this course, we'll dive into our current understanding of the evolution and ecology of parasitic interactions through primary literature, modeling, and experimental design. Throughout, we will focus on generating and testing hypotheses, evaluating theoretical models with evidence, drawing parallels between diverse domains of life, and connecting evolutionary and ecological ideas to today's past, present, and future epidemics.

Microbes rule. This course will teach microbial genomics using the cutting edge next-generation DNA sequencing technology and its applications to study microbes around us. Topics covered include microbial genomics, DNA sequencing and sequence analysis.

The evolutionary history of a population can be studied by examining patterns of genetic variation among individuals. Using information about genetic variation, we can infer historical evolutionary events like migration and adaptation. In this lab course, you will learn to utilize genomic data to conduct evolutionary inference. We will learn fundamentals of population genetics, bioinformatic skills, and research methods applied to real short-read sequencing data.

This course will provide an in-depth exploration of the field of regenerative biology, focusing on the molecular and cellular mechanisms underlying tissue regeneration and repair in animals. We will explore the cellular basis of different types of regeneration and search for shared molecular mechanisms. With an eye towards the future, we¿ll also explore the implications for advancing regenerative medicine.

This course introduces students to foundational and modern neuroscience research techniques through laboratory investigations. Neuroscience is explored at the molecular, systems, and behavioral level. Topics covered include neuroanatomy, electrophysiology, biopotentials, development, histology, and microscopy. An emphasis is placed on structure-function relationships, experimental design, and application of techniques in research.

This course for advanced undergrads will focus mainly on research about Alzheimer's disease, and will meet once/week for 3 hours. The first 3 weeks will be primarily didactic, and the remainder of the course will be a "journal club" in which primary research paper discussions will be led by teams of students. Assessments will be based on how well students lead and participate in discussions, and on exams.