We will learn to bridge the gap between the fields of bioengineering and the science of how drugs interact with biological systems, i.e., Pharmacology, including the principles of biochemical reaction kinetics and engineering; how such principles can help us describe, model, predict and modulate the outcome of biochemical reactions in cells and biological reactors, and apply these principles to the understanding of pharmacological phenomena. Prerequisites: BME 2104 AND APMA 2130

Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering. Topics vary by semester. Recent topics include Medical Imaging Systems Theory, BME Advanced Design, BME Electronics Lab, and Systems Biology Modeling and Experimentation. Prerequisite: third- or fourth-year standing or instructor permission.

Introduces techniques for constructing predictive or analytical engineering models for biological processes. Teaches modeling approaches using example problems in transport, mechanics, bioelectricity, molecular dynamics, tissue assembly & imaging. Problem sets include 1) linear systems and filtering 2) compartmental modeling 3) numerical techniques 4) finite element / finite difference models and 5) computational automata models. Prereq: CS 1110 or CS 1111 or CS 1112. Co-requisites: APMA 2130 or MATH 3250 or APMA 2501- Differential Equations & Linear Algebra or instructor permission.

Introduces biomaterials science and biological interactions with materials with overview of biomaterials testing (in vitro and in vivo) and characterization. Emphasis on emerging novel strategies and design of biomaterials. Areas of concentration include polymers and ceramics in biomaterials, drug delivery, tissue engineering (orthopaedic and vascular) and nanotechnology. Prerequisite: BME 2101, BME 2104, or instructor permission.

Introduces principles of continuum mechanics of biological tissues & systems. 1) Review results used in biomechanics field, 2) properties of living tissue; 3) mechanical basis & effects of pathology & trauma: 4) intro to mechanotransduction, circulatory transport, growth & remodeling & tissue-engineered materials; 5) low Reynolds number flows in vivo & microsystems. Prerequisites: APMA 2120 or MATH 2310 or MATH 2315 and BME Major or Minor

A year-long design project required for BME majors. Students select, formulate, and solve a design problem related to a device or a system. Projects use conceptual design, skills obtained in the integrated lab and substantial literature and patent reviews. Projects are sponsored by faculty, physicians and/or companies. Students may work on their own with outside team members when appropriate or with other students in integrative teams. Prerequisite: 4th year standing in the Biomedical Engineering major or instructor permission.

Introduces the physiology of the kidney, salt and water balance, gastrointestinal system, endocrine system, and central nervous system, with reference to diseases and their pathophysiology. Prerequisite: (CHEM 1410 or CHEM 1610 or CHEM 1810) AND (PHYS 1425 or PHYS 1420 or PHYS 1710) AND BME 2101, or instructor permission.

Provides a grounding in molecular biology and a working knowledge of recombinant DNA technology, thus establishing a basis for the evaluation and application of genetic engineering in whole animal systems. Beginning with the basic principles of genetics, this course examines the use of molecular methods to study gene expression, deliver viral and non-viral vectors, and its critical role in health. Prerequisite: BME 2101. Co-requisites: BME 2104.

Provides students with the skills necessary to engage in meaningful engineering design, and focuses on the latter stages of the engineering design process - detailed design, prototyping, and evaluation. Students develop skills in computer assisted design, embedded controls, prototyping, analysis and teamwork. A major focus of the class is the execution of a design project. Prerequisites: PHYS 1425, and BME major or minor. Recommended Corequisite: PHYS 2415 or ECE 2200.

Presents analytical tools used to model signals & linear systems. BME examples include multicompartment modeling of drug delivery, modeling of dynamic biomechanical systems & electrical circuit models of excitable cells. Topics: signals & systems, convolution, continuous time Fourier transforms, electrical circuits & applications of linear system theory. Prerequisite: PHYS 2415 & APMA 2130, & CS 1110 or equivalent