In a team, develop, prototype, and conduct verification and validation tests on engineering solutions to clinical challenges, demonstrating concept viability. Formal Design Control, Life Cycle, Risk Analysis, Project Management and Intellectual Property Strategies are introduced. Using Product Development Protocols, prepare a regulatory and implementation pathway analysis for commercialization into clinical practice. Prerequisite: BME 6550 Special Topics: Clinical Technology Continuum of Care

Focuses on the study of forces (and their effects) that act on the musculoskeletal structures of the human body. Based on the foundations of functional anatomy and engineering mechanics (rigid body and deformable approaches); students are exposed to clinical problems in orthopedics and rehabilitation. Cross-listed as AM 6280. Prerequisite: BME 6103.

Students will gain a fundamental understanding of the theoretical principles underlying biomedical measurements. Topics are organized sequentially from signal initiation through signal processing to downstream statistical analysis of measurements. Students will be exposed to the practical implementation of general principles through homework assignments that involve the analysis and evaluation of molecular, cellular, and clinical measurements. Prerequisites: 1. BME 6101: Physiology I (or equivalent) 2. SEAS graduate student status 3. Some previous exposure to probability-statistics, Fourier analysis, and linear systems 4. Or Instructor Permission

Introduces techniques for constructing mathematical and computational models of biological processes at many levels of organizational scale from genome to whole-tissue. Topics include choice of techniques, quantitative characterization of biological properties, assumptions and model simplification, parameter estimation and sensitivity analysis, model verification and validation and integration of computational modeling w/experimental approaches.Prerequisites: BME 6101, and BME 2104 or BME 7806 (or equivalent).

Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering. Topics vary by semester.

The course will cover human genetics and genomics, including the human/mammalian genome variation, determination of genomic variation on phenotype and disease risk, mapping and characterizing genetic variants on phenotype, determining the putative impact of genetic variants on gene expression (transcriptomics, epigenomics), the promise and implications of genome science on precision medicine and the ethical, legal & social implications.Pre-requisite: BIOL 3010 or BIOL 4210 or instructor consent.

Provides students with a quantitative framework for identifying and addressing important biological questions at the molecular, cell, and tissue levels. Focuses on the interplay between methods and logic, with an emphasis on the themes that emerge repeatedly in quantitative experiments. Prerequisites: BME 6101 (or equivalent), SEAS graduate student status, or instructor permission.

Provides biomedical engineers with a grounding in molecular biology and a working knowledge of recombinant DNA technology, thus establishing a basis for the evaluation and application of genetic engineering in whole animal systems. Beginning with the basic principles of genetics, this course examines the use of molecular methods to study gene expression and its critical role in health and disease. Topics include DNA replication, transcription, translation, recombinant DNA methodology, methods for analyzing gene expression (including microarray and genechip analysis), methods for creating genetically-engineered mice, and methods for accomplishing gene therapy by direct in vivo gene transfer. Prerequisite: BME 6103, undergraduate-level cell and/or molecular biology course. (e.g., BME 2104) or instructor permission. Suggested preparation: biochemistry, cell biology, genetics, and physiology..

For master's students.

FOR GRAD STUDENTS ONLY. A research project in biomedical engineering conducted in consultation with a faculty advisor. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Fulfills the project requirement for the Biomedical Engineering Masters of Engineering degree. Prereqs: Instructor Permission Required.