A journal club. Students present recent research papers in biophysics and/or report on progress of their own research projects. Students learn how to effectively read, critique, and present science research progress.

Designed on an individual basis, students who have deficiencies in particular areas pertaining to biophysics will be advised by a faculty member to read texts in that area and will discuss the contents with the faculty mentor on a regular basis.

This course is an advanced course targeted to Biophysics or Physiology graduate students providing a detailed introduction into macromolecular X-ray crystallography and cryo-electron microscopy. The course will be taught in two sections, (1) focus on X-ray crystallography and (2) on cryo-EM.

Exploration of magnetic resonance spectroscopy as it is applied to biopolymers. The first module will cover principles of nuclear magnetic resonance (NMR) will be covered, including basic principles, homonuclear and heteronuclear NMR methods. Prerequisite: BIOP 8201/8301, Biophysical Principles

Exploration of magnetic resonance spectroscopy as it is applied to biopolymers. Data collection for structure determination, residual dipolar couplings, approaches to large systems, and the use of NMR to deduce information about the dynamic behavior of proteins will be covered. Finally, principles of electron paramagnetic resonance spectroscopy will be presented. Prerequisite: BIOP 8030, Magnetic Resonance Spectroscopy of Macromolecules I

This course will introduce students to the theory, principles, and applications of the major techniques in cellular biophysics. Lectures will include practical background on instrumentation and data interpretation. A central focus will be on fluorescent microscopy and spectroscopy techniques. This course will also explore principles and methodologies of mechanobiology (e.g. Optical Tweezers, Atomic Force Microscopy).

The course will provide in-depth assessment of the structural biology of membrane proteins. Emphasis will be placed on the methodologies of solving membrane protein structure. The primary literature will be the main source of reading. The course will run as a colloquium with the instructors introducing a different topic at each session and students presenting relevant papers. The students will create a grant proposal for the final project.Prerequisite: BIOP 8130, Structure-Function of Biological Membranes

This course will introduce students to some of the physical and chemical underpinnings of molecular biophysics. Physical principles will be discussed and related to how they govern biological systems and how they enable important biophysical techniques. Topics: Equilibrium thermodynamics: mean behavior of ensembles at equilibrium, and Biological fluctuations: deviations from the meanPrerequisite: BIMS 6000

Development of faster and high-power biophysical methods has enabled scientists to study the structure, properties, dynamics and function of biomolecules at an atomic or molecular level and has revolutionized the field of biophysics. This module will introduce cutting-edge biophysical techniques and tools and how those could be useful for their own research. Relevant papers highlighting the applications will be discussed.

Independent study, other than non-topical research, for course credits.

For doctoral research, taken under the supervision of a dissertation director.