A first graduate course covering the theory and practice of discrete-event stochastic simulation. Coverage includes Monte Carlo methods and spreadsheet applications, generating random numbers and variates, specifying input probability distributions, discrete-event simulation logic and computational issues, review of basic queueing theory, analysis of correlated output sequences, model verification and validation, experiment design and comparison of simulated systems, and simulation optimization. Emphasis includes state-of-the-art simulation programming languages with animation on personal computers. Applications address operations in manufacturing, distribution, transportation, communication, computer, health care, and service systems.